Examples of antibiotic that is an acid stable penicillinase resistant include:
Resistance is the major problem with penicillins due to ability of bacteria to breakdown the lactam ring of penicillin and inactivates the drug. To overcome these problem penicillins can be administrated together with β-lactamase inhibitors.
Examples of β-lactamase inhibitors is/are:
I- Clavulanic acid
II- Sulbactam
III- Tazobactam
Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic patient in hospital who could not smoke?
Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.
Which of the following is the primary site of activity for the drug Warfarin?
Vitamin that requires an intrinsic factor to be carried out to ileum in order to suffer absorption from the small intestine:
Common etiologic agents of community-acquired pneumonia include:
I Escherichia coli
II Haemophilus influenzae
III Mycoplasma pneumoniae
Correct statements concerning vitamin E include:
I- It is a lipid soluble vitamin stored in adipose tissues
II- It is absorbed from the small intestine
III- Widely used in pharmaceutical formulations as antioxidant agent
Atropine is the primary example of an important class of muscarinic antagonists which are esters of tropic acid and which contain:
Which of the following reactions is controlled by the pancreatic hormone INSULIN?
The skeletal structure of the hipbone includes the:
I ilium
II ischium
III pubis
All are examples of drugs used in the treatment of bronchoconstriction, EXCEPT:
Dopamine is useful in the treatment of cardiogenic shock because it:
I selectively dilates renal and mesenteric vascular beds.
II does not induce peripheral vasoconstriction.
III decreases the force of myocardial contraction.
Which of the following agents or combinations may be appropriated to treat severe intermittent asthma?
Uricosuric agents are used in gout treatment by inhibiting the uric acid re-absorption in the proximal tubules, the best example of
a uricosuric agent is:
Characteristics of GOUT, a group of disorders of purine and pyrimidine metabolism may include:
I- Hereditary metabolite disease marked by inflammation of the joints
II- The joint inflammation is caused by precipitation of uric acid crystals
III- It is a type osteoporosis
The mechanism of antipsychotic effect of phenothiazines is thought to be due to:
Pannus is an inflammatory exudates characterized by:
I- Synovial cell proliferation inside of a joint
II- Normally occurs in patients with rheumatoid arthritis
III- An immunologic complication
Advantages of nasal route over oral route absorption of drugs may include:
I- Nasal route has a higher surface area
II- Nasal route has more blood vessels
III- Nasal route has a higher onset of absorption
Goals of gout treatment may include:
I- Reduce inflammation during acute attacks
II- Accelerate renal excretion of uric acid
III- Reduce the conversion of purine to uric acid
The style of management in which the owner of a pharmacy emphasizes the development of detailed policies and written procedures for employees to observe at all times is referred to as:
Indication of leukotrienes modifiers in the treatment of asthma includes which of the following?
I- Acute treatment
II- Prophylaxis
III- Chronic treatment
The major pathway for the biotransformation of the following compound is by hydrolysis. Identify the site which would be most susceptible to hydrolysis.
Mechanism of inhibit protein synthesis is characteristic of all the following antibiotics, EXCEPT:
Which of the following statements best describes the action of the antitubercular agent ISONIAZID?
Antibiotics that often cause colitis-acute inflammation of colon as side effect include:
I- Broad-spectrum penicillins
II- Cephalosporins
III- Clindamycin
Which of the following agents can be classified as macrolide antibiotics?
I- Azithromycin
II- Clarithromycin
III- Erythromycin
Drug of choice in the treatment of percutaneous blood infection-schistosomyasis may include: